InterventionHuman Growth Hormone Therapy
Alternate Name
OrganismRattus norvegicus
Aging PhenotypeNo effect on life-span
Allele TypeN/A
StrainF344
DescriptionSupplementation with up to 1 mg/kg of human growth hormone (HGH) twice weekly had no significant effect on mean, median, or maximum life-span (Kalu et al., 1998).
Gene FunctionGrowth hormone.
Other PhenotypesGH therapy at 50 mcg/kg body weight three times per week reversed the age-related decline in serum IGF-1 levels, returning it to that of 3 month old animals (Kalu et al, 1998). The prevalence of nephropathy, cardiomyopathy, leukemia, and testicular interstitial tumor, the main pathologic lesions in control animals was not altered by GH therapy (Kalu et al, 1998). Growth hormone therapy in mice also fails to extend life-span (Kalu et al., 1998)
HomologsN/A
Primary ReferenceKalu, D. N., Orhii, P. B., Chen, C., Lee, D. Y., Hubbard, G. B., Lee, S., and Olatunji-Bello, Y. (1998). Aged-rodent models of long-term growth hormone therapy: lack of deleterious effect on longevity, J Gerontol A Biol Sci Med Sci 53, B452-63. [Abstract]
Other References
Relevant Links
Keywordsrat, cancer, endocrine, insulin-like growth factor 1, signaling