OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionHeterozygous knock-down of the insulin-like growth factor receptor IGF-1R results in a 33% increase in the mean life-span of female animals (Holzenberger et al., 2002). Male heterozygotes show a 16% increase in mean life-span that fails to reach statistical significance.
Gene FunctionReceptor tyrosine kinase.
Other PhenotypesFemale IGF-1R heterozygotes have normal body size, energy metabolism, food and water intake, physical activity, nutrient uptake, glucose regulation, serum insulin, serum glucose, and fertility (Holzenberger et al., 2002). Heterozygotes are more resistant to paraquat and IGF-1R +/- MEFs are more resistant to hydrogen peroxide than +/+. Animals homozygous for mutation of IGF-1R are inviable at birth (Liu et al., 1993).
HomologsC.e. daf-2
D.m. InR, sev
R.n. Ig1r, InsR
M.m. Insr
Primary ReferenceHolzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Geleon, A., Even, P. C., Cervera, P., Le Bouc, Y. (2002) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. Advanced Online Publication. December 4.
Other ReferencesLiu, J. P., Baker, J., Perkins, A. S., Robertson, E. J., and Efstratiadis, A. (1993). Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75, 59-72. [Abstract]
Relevant LinksLocusLink:
Keywordsinsulin, signaling, dwarf, oxidative stress, mouse