Namehuman tau
OrganismDrosophila melanogaster
Aging PhenotypeShortened life-span
Allele TypeOverexpression
DescriptionExpression of wild-type human tau moderately shortened life-span. Expression of a mutant form of human tau (Arg406 Trp), associated with an early onset familial form of dementia, results in a severely shortened life-span (Wittmann et al., 2001).
Gene Functionmicrotubule-binding protein
Other PhenotypesTau has been implicated in the pathogenesis of Alzheimer`s disease and related disorders in humans. Transgenic flies showed key features of the human disorders: adult onset, progressive neurodegeneration, early death, enhanced toxicity of mutant tau, accumulation of abnormal tau, and relative anatomic selectivity. However, neurodegeneration occurred without the neurofibrillary tangle formation that is seen in human disease and some rodent tauopathy models (Wittmann et al., 2001).
Primary ReferenceWittmann, C. W., Wszolek, M. F., Shulman, J. M., Salvaterra, P. M., Lewis, J., Hutton, M., and Feany, M. B. (2001). Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 293, 711-4. [Abstract]
Other References
Relevant Links
Keywordsflies, neurodegeneration, Alzheimer disease, protein aggregation