InterventionFish oil
Alternate Name(n-3) Fatty acids
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainAutoimmune-Prone (NZB x NZW)F(1)
DescriptionSubstitution of fish oil for corn oil (5g/100g total diet) in the diets of autoimmune prone mice extended life-span by approximately 40% (345 d v. 242 d) compared to ad-lib corn oil (AL/CO) fed controls (Jolly et al., 2001). Calorie restricted corn oil fed animals (CR/CO) lived twice as long as AL/CO controls (494 d) and CR fish oil fed animals lived 2.7 times as long (645 d) as AL/CO fed animals.
Gene FunctionN/A
Other PhenotypesIncreased life-span was partially associated with decreased body weight, blunting renal proinflammatory cytokine (interferon-, interleukins-10 and -12 and tumor necrosis factor-) levels and lower nuclear factor-B (NF-B). Reductions in NF-B were preceded by enhanced superoxide dismutase, catalase and glutathione peroxidase activities (Jolly et al., 2001).
Homologs
Primary ReferenceJolly, C. A., Muthukumar, A., Avula, C. P., Troyer, D., and Fernandes, G. (2001). Life span is prolonged in food-restricted autoimmune-prone (NZB x NZW)F(1) mice fed a diet enriched with (n-3) fatty acids. J Nutr 131, 2753-60. [Abstract]
Other References
Relevant Links
Keywordsimmune response, caloric restriction, dietary restrction, DR, fat, mouse, nutrition