InterventionAxenic growth
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainN2
DescriptionGrowth in axenic culture (soy peptone + yeast extract without E. coli) extends median life-span by approximately 40% compared to growth in monoxenic culture (Hoothoofd et al., 2002).
Gene FunctionN/A
Other PhenotypesGrowth in axenic culture increases oxygen consumption and heat production compared to monoxenic culture (Houthoofd et al., 2002).. Axenically grown animals also demonstrate increased superoxide dismutase and catalase activity.
Homologs
Primary ReferenceHouthoofd, K., Braeckman, B. P., Lenaerts, I., Brys, K., De Vreese, A., Van Eygen, S., and Vanfleteren, J. R. Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in C. elegans. Exp Gerontol In Press, Uncorre
Other References
Relevant Links
Keywordscalorie restriction, caloric, CR, metabolism, oxygen consumption, oxidative stess