OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeN/A
DescriptionDeletion of TPS2 has no effect on life-span and does not prevent life-span extension by high osmolarity (Kaeberlein et al., 2002).
Gene FunctionTrehalose-6-phosphate synthase
Other PhenotypesTPS2 is required for trehalose biosynthesis in response to osmotic stress (De Virgilio et al., 1993).
HomologsS.p. TPP1
Primary ReferenceKaeberlein, M., Andalis, A. A., Fink, G. R., and Guarente, L. (2002). High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction. Mol Cell Biol 22, 8056-66. [Abstract]
Other ReferencesDe Virgilio, C., Burckert, N., Bell, W., Jeno, P., Boller, T., and Wiemken, A. (1993). Disruption of TPS2, the gene encoding the 100-kDa subunit of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae, causes accumulation of [Abstract]
Relevant LinksSGD:
Keywordssalt, osmotolerance, replicative senescence, CR, calorie restriction, high osmolarity glycerol