NameGPD1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeN/A
StrainPSY316
DescriptionDeletion of GPD1 shortens life-span by 25% and prevents life-span extension by high osmolarity (Kaeberlein et al., 2002).
Gene FunctionGlycerol-3-phosphate dehydrogenase
Other PhenotypesTranscriptional regulation of GPD1 by osmotic stress requires HOG1 (Albertyn et al., 1994).
HomologsS.p. GPDA
C.e. GPDA
D.m. GPDA
R.n. GPDA
M.m. GPDA
H.s. GPDA
Primary ReferenceKaeberlein, M., Andalis, A. A., Fink, G. R., and Guarente, L. (2002). High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction. Mol Cell Biol 22, 8056-66. [Abstract]
Other ReferencesAlbertyn, J., Hohmann, S., Thevelein, J. M., and Prior, B. A. (1994). GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=GPD1
Keywordssalt, osmotolerance, replicative senescence, CR, calorie restriction, high osmolarity glycerol