OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeN/A
DescriptionDeletion of HOG1 shortens life span by 25% and prevents life-span extension by high osmolarity (Kaeberlein et al., 2002).
Gene FunctionN/A
Other PhenotypesHOG1 is required for many of the transcriptional responses to high osmolarity, including increased glycerol biosynthesis and MSN2/MSN4-dependent stress response (Rep et al., 2000).
HomologsS.p. STY1
D.m. P38B
R.n. MAPK14
M.m. MAPK14
H.s. MAPK14
Primary ReferenceKaeberlein, M., Andalis, A. A., Fink, G. R., and Guarente, L. (2002). High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction. Mol Cell Biol 22, 8056-66. [Abstract]
Other ReferencesRep, M., Krantz, M., Thevelein, J. M., and Hohmann, S. (2000). The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes. [Abstract]
Relevant LinksSGD:
Keywordssalt, osmotolerance, replicative senescence, CR, calorie restriction, high osmolarity glycerol