Intervention60% Oxygen
Alternate Name
OrganismRattus norvegicus
Aging PhenotypeShortened life-span
Allele TypeN/A
StrainFischer 344
DescriptionGrowth of female rats under 60% oxygen shortened median life-span by approximately 30% and maximum life-span by approximately 10% compared to growth at atmospheric oxygen concentration (Gomi and Matsuo, 2002).
Gene FunctionN/A
Other PhenotypesTranscription of antioxidant enzymes such as catalase and superoxide dismutase is increased under 60% oxygen (Gomi and Matsuo, 2002).
Primary ReferenceGomi, F., and Matsuo, M. (2002). Effects of 60% oxygen inhalation on the survival and antioxidant enzyme activities of young and old rats. Mech Ageing Dev 123, 1295. [Abstract]
Other References
Relevant Links
Keywordsoxidative stress, antioxidant, rat