Nameclk-2
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionAt 20C, development is slowed down and adult life span is extended (Lakowski and Hekimi, 1996).
Gene FunctionInvolved in regualting telomere length (Lim et al., 2001; Benard et al., 2001) and DNA damage response (Ahmed et al., 2001)
Other PhenotypesMutant shows slow growth and rhythms similar to clk-1. Profound maternal and zygotic rescue. Mutation is embryonic lethal at 25C and results in some lethality at all temperatures (Lakowski and Hekimi, 1996).

Mutation of clk-2 affects telomere length. One report states that clk-2 mutation results in shorter telomeres (Lim et al., 2001); however a second report contradicts this and claims that mutation of clk-2 results in elongated telomeres while overexpression shortens telomeres (Ahmed et al., 2001). Recently, CLK-2 was found to be identical to RAD-5, a DNA damage checkpoint protein.

HomologsN/A
S.c. TEL2
S.c. TEL2
Primary ReferenceLakowski, B., and Hekimi, S. (1996). Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272, 1010-3. [Abstract]
Other ReferencesLim, C. S., Mian, I. S., Dernburg, A. F., and Campisi, J. (2001). C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p. Curr Biol 11, 1706-10. [Abstract]
Ahmed, S., Alpi, A., Hengartner, M. O., and Gartner, A. (2001). C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Curr Biol 11, 1934-1944. [Abstract]
Benard, C., McCright, B., Zhang, Y., Felkai, S., Lakowski, B., and Hekimi, S. (2001). The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development 12 [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=clk-2
WormPD: http://www.proteome.com/databases/WormPD/reports/clk-2.html
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=176065
KeywordsCaenorhabditis, elegans, worm, metabolism, telomeres, DNA damage