InterventionCaloric restriction
Alternate Name
OrganismCanis lupus familiaris
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainLabrador retriever
DescriptionA 25% reduction in caloric intake in labrador retriever dogs results in a 16% increase in median life-span (p < 0.01) (Kealy et al., 2002). Dogs were fed a calorically restricted diet beginning at 8 weeks of age. Median life-span was 11.2 years for control-fed dogs and 13.0 years for calorically restricted dogs.
Gene FunctionN/A
Other PhenotypesCalorically restricted dogs have decreased body mass, fat content, serum triglycerides, triiodothyronine, insulin and glucose levels compared to control-fed dogs (Kealy et al., 2002). Dietary restriction also increases bone mass (Kealy et al., 2002), decreases osteoarthritis (Kealy et al., 1997), and decreases the incidence of hip dysplasia (Kealy et al., 1992).
HomologsN/A
Primary ReferenceKealy, R. D., Lawler, D. E., Ballam, J. M., Mantz, S. L., Biery, D. N., Greeley, E. H., Lust, G., Segre, M., Smith, G. K., and Stowe, H. D. (2002). Effects of diet restriction on life span and age-related changes in dogs. J Am Vet Med Assoc 220, 1315-20. [Abstract]
Other ReferencesKealy, R. D., Olsson, S. E., Monti, K. L., Lawler, D. F., Biery, D. N., Helms, R. W., Lust, G., and Smith, G. K. (1992). Effects of limited food consumption on the incidence of hip dysplasia in growing dogs. J Am Vet Med Assoc 201, 857-63. [Abstract]
Kealy, R. D., Lawler, D. F., Ballam, J. M., Lust, G., Smith, G. K., Biery, D. N., and Olsson, S. E. (1997). Five-year longitudinal study on limited food consumption and development of osteoarthritis in coxofemoral joints of dogs. J Am Vet Med Assoc 210, 2 [Abstract]
Relevant Links
KeywordsCanis, dog, labrador, retriever, caloric restriction, metabolism, dietary restriction, calorie restriction bibliography