OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeN/A
Allele TypeUnknown
DescriptionA temperature sensitive allele of ATP2 causes daughter cells derived from mother cells aged at 36C to have a life-span equal to that of the mother cells (Lai et al., 2002).
Gene FunctionBeta subunit of the mitochondrial F1-F0 ATPase.
Other PhenotypesThe valine to isoleucine mutation at amino acid 90 does not affect growth on non-fermentable carbon sources (Lai et al., 2002). This allele is associated with loss of mitochondrial membrane potential and failure to segregate functional mitochondria to daughter cells.
HomologsS.p. ATP2
C.e. C34E10.6
D.m. ATPSYN-beta
R.n. ATP5B
M.m. ATP5B
H.s. ATP5B
Primary ReferenceLai, C. Y., Jaruga, E., Borghouts, C., and Jazwinski, S. M. (2002). A Mutation in the ATP2 Gene Abrogates the Age Asymmetry Between Mother and Daughter Cells of the Yeast Saccharomyces cerevisiae. Genetics 162, 73-87. [Abstract]
Other References
Relevant LinksSGD:
Keywordsyeast, replicative life-span, mitochondria, segregation