OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionA transposon mutagenized allele of CYR1 results in a 90% increase in chronological life-span (Fabrizio et al., 2001).
Gene FunctionAdenylate cyclase. Generates cAMP in response to RAS activation.
Other PhenotypesNull mutant arrest at G1 phase is rescued by exogenous cAMP (Matsumoto et al., 1982). A transposon mutagenized allele of CYR1 results in resistance to hydrogen peroxide, and resistance to heat shock (Fabrizio et al., 2001).
Deletion of SOD2 fails to prevent the increased stationary phase survival caused by mutation of CYR1. (Fabrizio et al., 2003)
The cdc35-1 allele confers a 75% extension of replicative life-span at 25C (Lin et al., 2000).
HomologsS.c. PTC1, SDS22, NUD1
S.p. ptc3, ptc1
C.e. F43C1.1, LET-413, SOC-2
D.m. CG5462, CG5407, SCRIB
H.s. LOC55914
Primary ReferenceFabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., and Longo, V. D. (2001). Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-90. [Abstract]
Other ReferencesLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Matsumoto, K., Uno, I., Oshima, Y., and Ishikawa, T. (1982). Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 79, 2355-9. [Abstract]
Fabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46. [Abstract]
Relevant LinksSGD:
Keywordscaloric restriction, metabolism, signaling, cell cycle, replicative senescence, S. cerevisiae, yeast, stationary phase, oxidative stress