NameSOD1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainSP-4
DescriptionDeletion of Cu-Zn superoxide dismutase decreases replicative life-span by approximately 40% (Wawryn et al., 2002). The magnitude of the decrease in life-span does not appear to be dependent on oxygen concentration in the atmosphere.
Gene FunctionCytosolic copper-zinc superoxide dismutase.
Other PhenotypesDeletion of SOD1 shortens chronological life-span as well as replicative life span (Longo et al., 1999). Overexpression of SOD1 has no effect on replicative life-span (Kirchman et al., 1999).
HomologsS.p. SOD1
C.e. sod-1, C15F1.7, ZK430.3
D.m. sod, CG9027, CG17753
R.n. Sod1, Sod3
M.m. Sod1, Ccsd, Sod3
H.s. SOD1, CCS, SOD3
Primary ReferenceWawryn, J., Swiecilo, A., Bartosz, G., and Bilinski, T. (2002). Effect of superoxide dismutase deficiency on the life span of the yeast Saccharomyces cerevisiae. An oxygen-independent role of Cu,Zn- superoxide dismutase. Biochim Biophys Acta 1570, 199-202 [Abstract]
Other ReferencesKirchman, P. A., Kim, S., Lai, C. Y., and Jazwinski, S. M. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae, Genetics 152, 179-90. [Abstract]
Longo, V. D., Liou, L. L., Valentine, J. S., and Gralla, E. B. (1999). Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 365, 131-42. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=sod1
KeywordsSaccharomyces, cerevisiae, yeast, oxidative stress, stationary phase survival, replicative senescence