InterventionMelatonin
Alternate NameN-acetyl-5-methoxy-triptamine
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainFemale CBA
DescriptionDietary supplementation with 20mg/L melatonin resulted in an approximately 5% increase in the mean life span of femal CBA mice (Anisimov et al., 2001).
Gene FunctionMelatonin is a hormone synthesized by the pineal gland and has a wide range of effects on endocrine and reproductive functions.
Other PhenotypesMelatonin supplementation also increased spontaneous tumor formation in mice treated with this regimen (Anisimov et al, 2001).
Homologs
Primary ReferenceAnisimov, V. N., Zavarzina, N. Y., Zabezhinski, M. A., Popovich, I. G., Zimina, O. A., Shtylick, A. V., Arutjunyan, A. V., Oparina, T. I., Prokopenko, V. M., Mikhalski, A. I., and Yashin, A. I. (2001). Melatonin increases both life span and tumor incidenc [Abstract]
Other References
Relevant Links
Keywordsmouse, hormone, oxidative stress