OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
DescriptionDeletion of CYT1 has no effect on life-span, but prevents life-span extension by overexpression of HAP4 (Lin et al., 2002).
Gene FunctionCytochrome c1.
Other PhenotypesCYT1 is required for respiration in yeast.
HomologsM.m. CYC1
H.s. CYC1
Primary ReferenceLin, S. J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P. A., Culotta, V. C., Fink, G. R., and Guarente, L. (2002). Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344-8. [Abstract]
Other References
Relevant LinksSGD:
Keywordsoxygen, oxidative stress, yeast, replicative senescence, fermentation, respiration, mitochondria, electron transport, caloric restriction