Interventionalpha-phenyl-N-t-butyl-nitrone
Alternate NamePBN
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainC57BK/6J, SAM-P8
DescriptionPBN extends the life-span of SAM-P8 (senescence accelerated mouse) mice approximately 33% when administered via intraperitoneal (IP) injections starting at the age of 3 months (Edamatsu et al. 1995). A subsequent study in C57BK/6J mice demonstrated small, but significant, increases in life-span when treatment was begun in older adults (24.5 mo)(Saito et al. 1998).
Gene FunctionNitrones are free radical traps, but it has been suggested that the neuroprotective and anti-aging activities of nitrones do not result from mass action free radical quelling activity (Floyd et al. 2002).
Other PhenotypesNitrones have broad neuroprotective effects (reviewed in Floyd et al., 2002).
PBN has been reported to extend the replicative life-span of human cells, but failed to extend life-span in houseflies.
HomologsN/A
Primary ReferenceEdamatsu, R., Mori, A., and Packer, L. (1995). The spin-trap N-tert-alpha-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse. Biochem Biophys Res Commun 211, 847-9. [Abstract]
Other ReferencesFloyd, R. A., Hensley, K., Forster, M. J., Kelleher-Andersson, J. A., and Wood, P. L. (2002). Nitrones, their value as therapeutics and probes to understand aging. Mech Ageing Dev 123, 1021-31. [Abstract]
Saito, K., Yoshioka, H., and Cutler, R. G. (1998). A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice. Biosci Biotechnol Biochem 62, 792-4. [Abstract]
Relevant Links
KeywordsReactive oxygen species, oxygen free radicals, neurodegeneration, neuroinflamation, oxidative stress, spin-trap CPI-1429, spin-trap