Alternate NameSelegiline
OrganismRattus norvegicus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainFischer 344 (male)
DescriptionMale rats were injected subcutaneously with (-) deprenyl three times weekly, beginning at 18 months of age. This treatment resulted in a significant life-span extension (Kitani et al, 1993).
In a different study, treatment with deprenyl (0.5 mg/Kg) for up to 20 months significantly increased mortality in the male Wistar rat (Gallagher et al., 1998).
Similar treatments have been found to increase life-span in mice, dogs, and hamsters. However, it should also be noted there are a number of reports of failure of (-)deprenyl treatment to extend life-span and shortening of lifespan by (-)deprenyl treatment has also been reported (reviewed in Kitani et al., 2002).
Gene FunctionN/A
Other Phenotypes(-) deprenyl is a MAO B (monoamine oxidase) inhibitor (Knoll, 1980) with anti-apoptotic and neuroprotective effects (Tatton et al, 1994; Olanow, 1996; Paterson et al, 1997; Maruyama and Naoi, 1999). (-) deprenyl can induce increases in superoxide dismutase (SOD) and catalase (CAT) activities in certain regions of the brain (Carillo et al, 1992) and spleen (ThyagaRajan et al, 2000). (-)deprenyl also mobilizes several humoral factors, including neurotrophic factors, TNF-alpha, and several interleukins (Tang et al, 1998; Muller et al, 1996; ThyagaRajan et al, 1998). (-)deprenyl treatment causes a reduction in incidence of tumors with age (Kitani et al, 1993).
Primary ReferenceKitani, K., Kanai, S., Sato, Y., Ohta, M., Ivy, G. O., and Carrillo, M. C. (1993). Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats. Further evidence. Life Sci 52, 281-8. [Abstract]
Other ReferencesKnoll, J. (1988). The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl. Mech Ageing Dev 46, 237-62. [Abstract]
Milgram, N. W., Racine, R. J., Nellis, P., Mendonca, A., and Ivy, G. O. (1990). Maintenance on L-deprenyl prolongs life in aged male rats. Life Sci 47, 415-20. [Abstract]
Kitani, K., Minami, C., Isobe, K., Maehara, K., Kanai, S., Ivy, G. O., and Carrillo, M. C. (2002). Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of vari [Abstract]
Archer, J. R., and Harrison, D. E. (1996). L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males. J Gerontol A Biol Sci Med Sci 51, B448-53. [Abstract]
Ruehl, W. W., Entriken, T. L., Muggenburg, B. A., Bruyette, D. S., Griffith, W. C., and Hahn, F. F. (1997). Treatment with L-deprenyl prolongs life in elderly dogs. Life Sci 61, 1037-44. [Abstract]
Stoll, S., Hafner, U., Kranzlin, B., and Muller, W. E. (1997). Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males. Neurobiol Aging 18, 205-11. [Abstract]
Ingram, D. K., Wiener, H. L., Chachich, M. E., Long, J. M., Hengemihle, J., and Gupta, M. (1993). Chronic treatment of aged mice with L-deprenyl produces marked striatal MAO-B inhibition but no beneficial effects on survival, motor performance, or nigral [Abstract]
Bickford, P. C., Adams, C. E., Boyson, S. J., Curella, P., Gerhardt, G. A., Heron, C., Ivy, G. O., Lin, A. M., Murphy, M. P., Poth, K., Wallace, D. R., Young, D. A., Zahniser, N. R., and Rose, G. M. (1997). Long-term treatment of male F344 rats with depre [Abstract]
Gallagher, I. M., Clow, A., and Glover, V. (1998). Long-term administration of (-)-deprenyl increases mortality in male Wistar rats. J Neural Transm Suppl 52, 315-20. [Abstract]
Knoll, J. (1980). Deprenyl (selegeline): the history of its development and pharmaceutical action. Acat Neurol Scand Suppl 95, 57-80.
Tatton, W. G., Ju, W. Y., Holland, D. P., Tai, C., and Kwan, M. (1994). (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. J Neurochem 63, 1572-5. [Abstract]
Olanow, C. W. (1996). Deprenyl in the treatment of Parkinson's disease: clinical effects and speculations on mechanism of action. J Neural Transm Suppl 48, 75-84.
Paterson, I. A., Barber, A. J., Gelowitz, D. L., and Voll, C. (1997). (-)Deprenyl reduces delayed neuronal death of hippocampal pyramidal cells. Neurosci Biobehav Rev 21, 181-6. [Abstract]
Maruyama, W., and Naoi, M. (1999). Neuroprotection by (-)-deprenyl and related compounds. Mech Ageing Dev 111, 189-200. [Abstract]
Carrillo, M. C., Kitani, K., Kanai, S., Sato, Y., and Ivy, G. O. (1992). The ability of (-)deprenyl to increase superoxide dismutase activities in the rat is tissue and brain region selective. Life Sci 50, 1985-92. [Abstract]
ThyagaRajan, S., Madden, K. S., Stevens, S. Y., and Felten, D. L. (2000). Restoration of splenic noradrenergic nerve fibers and immune reactivity in old F344 rats: a comparison between L-deprenyl and L- desmethyldeprenyl. Int J Immunopharmacol 22, 523-36. [Abstract]
ThyagaRajan, S., Madden, K. S., Kalvass, J. C., Dimitrova, S. S., Felten, S. Y., and Felten, D. L. (1998). L-deprenyl-induced increase in IL-2 and NK cell activity accompanies restoration of noradrenergic nerve fibers in the spleens of old F344 rats. J Ne [Abstract]
Tang, Y. P., Ma, Y. L., Chao, C. C., Chen, K. Y., and Lee, E. H. (1998). Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments. J Neurosci Res 53, 593-604. [Abstract]
Relevant Links
Keywordsdeprenyl, selegiline, selegeline, Rattus norvegicus, SOD, superoxide dismutase, CAT, catalase, oxidative stress, oxidative damage, radicals, cancer, tumor, spleen, immune, humoral