OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainBristol N2
DescriptionC. elegans hsp70F is the homolog of mammalian mortalin (mot-2/mthsp70/Grp75) (Heschl and Baillie, 1989), which has been shown to be capable of increasing the proliferative potential of normal fibroblasts when overexpressed (Kaula et al, 2000). Overexpression of hsp70F from a muscle-specific promoter increased life-span (mean increase: 43%, maximum increase: 45%) relative to animals expressing GFP from the same promoter (Yokoyama et al, 2002).
Gene FunctionUnkown. Possible heat shock protein.
Other PhenotypesThe hsp70F transgene was integrated into the genome, not an extrachromosomal array. It was confirmed immunohistochemically to be expressed predominantly in muscle (Yokoyama et al, 2002).
Primary ReferenceYokoyama, K., Fukumoto, K., Murakami, T., Harada, S., Hosono, R., Wadhwa, R., Mitsui, Y., and Ohkuma, S. (2002). Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. FEBS Lett 516 [Abstract]
Other ReferencesKaul, S. C., Reddelb, R. R., Sugiharac, T., Mitsuia, Y., and Wadhwa, R. (2000). Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2. FEBS Lett 474, 159-64. [Abstract]
Heschl, M. F., and Baillie, D. L. (1989). Characterization of the hsp70 multigene family of Caenorhabditis elegans. Dna 8, 233-43. [Abstract]
Relevant LinksLocusLink:
KeywordsHeat shock, Caenorhabditis elegans, worms