OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeDeletion
Strain129Ola and BalbC
DescriptionMice homozygous for disruption of GHR/BP have a life-span that is 40-50% longer than wild type or heterozygous mice (Coschigano et al., 2000).
Gene FunctionGrowth hormone receptor / growth hormone binding protein.
Other PhenotypesThe GHR/BP knockout mouse is a model for the rare human disease Laron syndrome (Zhou et al., 1997). Serum levels of GH are elevated in mutant mice (Zhou et al., 1997). Mutant mice are smaller than wild type mice. IGF-I and IGFBP-3 levels are also reduced in mutant mice (Coschigano et al., 2000). Age associated declines in memory retention have been reported to be delayed in mutant mice (Kinney et al., 2001).
HomologsR.n. GHR
H.s. GHR
Primary ReferenceCoschigano, K. T., Clemmons, D., Bellush, L. L., and Kopchick, J. J. (2000). Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141, 2608-13. [Abstract]
Other ReferencesZhou, Y., Xu, B. C., Maheshwari, H. G., He, L., Reed, M., Lozykowski, M., Okada, S., Cataldo, L., Coschigamo, K., Wagner, T. E., Baumann, G., and Kopchick, J. J. (1997). A mammalian model for Laron syndrome produced by targeted disruption of the mouse gro [Abstract]
Kinney, B. A., Coschigano, K. T., Kopchick, J. J., Steger, R. W., and Bartke, A. (2001). Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice. Physiol Behav 72, 653-60. [Abstract]
Relevant LinksKO Mouse:;2002/8/tg1
Keywordsgrowth hormone, insulin, dwarfism, Laron, mouse