InterventionDecreased oxygen concentration
Alternate Name
OrganismHomo sapiens (cell culture)
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainIMR-90 fibroblast
DescriptionReducing the ambient oxygen concentration from 20% (air) to 3% results in a 50% increase in replicative capacity of human fibroblasts (Chen et al., 1995).
Gene FunctionN/A
Other PhenotypesReducing the oxygen concentration from 20% (air) to 3% results in a much larger increase (200-300%) in replicative capacity of mouse fibroblast cells (Campisi, 2001).
HomologsN/A
Primary ReferenceChen, Q., Fischer, A., Reagan, J. D., Yan, L. J., and Ames, B. N. (1995). Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci U S A 92, 4337-41. [Abstract]
Other ReferencesCampisi, J. (2001). From cells to organisms: can we learn about aging from cells in culture? Exp Gerontol 36, 607-18. [Abstract]
Relevant Links
Keywordshuman, fibroblast, cell culture, oxidative stress