OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
DescriptionDeletion of CIT2 has no effect on life-span (Kirchman et al., 1999). CIT2 is not required for the strain specific life-span extension in petite cells. Overexpression of CIT2 has no effect on life-span (Kirchman et al., 1999).
Gene FunctionPeroxisomal citrate synthase.
Other PhenotypesCIT2 is transcribed up to 30-fold higher in petite cells relative to grande cells (Liao et al., 1991).
HomologsS.c. CIT1
S.p. SPAC6C3.04
C.e. T20G5.2
D.m. CG3861, CG14740
H.s. CS
Primary ReferenceKirchman, P. A., Kim, S., Lai, C. Y., and Jazwinski, S. M. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae, Genetics 152, 179-90. [Abstract]
Other ReferencesLiao, X. S., Small, W. C., Srere, P. A., and Butow, R. A. (1991). Intramitochondrial functions regulate nonmitochondrial citrate synthase (CIT2) expression in Saccharomyces cerevisiae. Mol Cell Biol 11, 38-46. [Abstract]
Relevant LinksYPD:|Sep 20 2001 11:26:00:526AM
KeywordsMetabolism, Mitochondria, replicative senescence, Saccharomyces, cerevisiae, peroxisomes