NameMSRA
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainN/A
DescriptionFlies engineered to overexpress methionine sulfoxide reductase A (MSRA) have a median lifespan up to 70% longer than parental controls that don't overexpress the protein (Ruan et al., 2002).
Gene FunctionMSRA reduces methionine sulofoxide to methionine.
Other PhenotypesFlies that overexpress MSRA retain reproductive capacity longer than parental controls that don't overexpress the protein, and are more active, as measured by a climbing assay (Ruan et al., 2002).
HomologsM. m. MsrA
R.n. MsrA
Primary ReferenceRuan, H., Tang, X. D., Chen, M. L., Joiner, M. A., Sun, G., Brot, N., Weissbach, H., Heinemann, S. H., Iverson, L., Wu, C. F., and Hoshi, T. (2002). High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proc Natl Acad Sci U S A
Other References
Relevant LinksLocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=39675
FlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0000565
Keywordsoxidative damage, fly, Drosophila melanogaster