OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
Descriptionpgl-1(bn101) animals that are sterile have a life-span that is approximately 35% longer than wild type animals. Fertile pgl-1(bn101) animals have a wild type life-span (Arantes-Oliveira et al., 2002).
Gene FunctionComponent of germ line P-granules.
Other PhenotypesPGL-1 is required for fertility and proliferation of germ line cells (Kawasaki et al., 1998).
HomologsS.c. MUC1
S.p. Spbc1711.05
C.e. C18G1.4, B0523.3, F35C5.3
Primary ReferenceArantes-Oliviera, N., Apfeld, J., Dillin, A., and Kenyon, C. (2002). Regulation of life-span by germ line stem cells in Caenorhabditis elegans. Science 295. [Abstract]
Other ReferencesKawasaki, I., Shim, Y. H., Kirchner, J., Kaminker, J., Wood, W. B., and Strome, S. (1998). PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans. Cell 94, 635-45. [Abstract]
Relevant LinksWormBase:;class=Locus
KeywordsCaenorhabditis, elegans, worm, sterility,