InterventionD-sorbitol
Alternate Name
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainW303R, PSY316
DescriptionGrowth on media supplemented with 1M D-sorbitol results in a 35% increase in mean life span (Kaeberlein et al., 2002). Addition of 1M D-sorbitol to the growth media suppresses the short life-span of an mpt5 mutant (Kaeberlein and Guarente, 2002).
Gene FunctionD-sorbitol is an acyclic polyol that is commonly added to media to allow growth of cells with a defective cell wall.
Other PhenotypesAddition of 1M sorbitol to the growth media suppresses the temperature sensitive growth of an mpt5 mutant and allows growth of ccr4 mpt5 ssd1-d cells (Kaeberlein and Guarente, 2002).
Homologs
Primary ReferenceKaeberlein, M., Andalis, A. A., Fink, G. R., and Guarente, L. (2002). High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction. Mol Cell Biol 22, 8056-66. [Abstract]
Other ReferencesKaeberlein, M., and Guarente, L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160, 83-95. [Abstract]
Kaeberlein, M., and Guarente, L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160, 83-95. [Abstract]
Relevant Links
KeywordsSaccharomyces cerevisiae, yeast, replicative, senescence, cell wall, osmotic stress