NameCCR4
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainW303R
DescriptionDeletion of CCR4 shortens life-span by approximately 80% (Kaeberlein and Guarente, 2002). SSD1-V partially suppresses the short life-span of a ccr4 mutant.
Gene FunctionTranscription factor involved in nonfermentative growth and cell wall stability (Denis, 1984; Chang et al., 1999).
Other PhenotypesMutation of ccr4 results in temperature sensitivity that is suppressed by SSD1-V (Kaeberlein and Guarente, 2002). Mutation of ccr4 is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V (Kaeberlein and Guarente, 2002).
HomologsS.c. Ngl1p, Ngl2p, Cyr1p
S.p. Spcc5e4.02c, Spbc9b6.11c
C.e. ZC518.3, W02G9.5, SOC-2
D.m. CG5534, CG17741, CG4796
R.n. LOC117284, LUM, SCOP
M.m. CCR4, RSU1, FLIIH
H.s. CCRN4L, SHOC2
Primary ReferenceKaeberlein, M., and Guarente, L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 Function in Parallel Pathways to Promote Cell Wall Integrity. Genetics 160, 83-95. [Abstract]
Other ReferencesDenis, C. L. (1984). Identification of new genes involved in the regulation of yeast alcohol dehydrogenase II. Genetics 108, 833-44. [Abstract]
Chang, M., French-Cornay, D., Fan, H. Y., Klein, H., Denis, C. L., and Jaehning, J. A. (1999). A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Mol Cell Biol 19, 1056-67. [Abstract]
Relevant LinksYPD: http://www.proteome.com/databases/YPD/reports/ccr4.html
SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=ccr4
KeywordsSaccharomyces cerevisiae, yeast, replicative, senescence, cell wall, transcription factor, signalling,