OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionDeletion of SWI4 shortens life-span by approximately 90% (Kaeberlein and Guarente, 2002). SSD1-V partially suppresses the short life-span of a swi4 mutant.
Gene FunctionSBF transcription factor involved in regulating G1 cyclins and cell wall stability (Nasmyth and Dirick, 1991; Igual et al., 1996).
Other PhenotypesMutation of swi4 results in slow growth and temperature sensitivity, both of which are suppressed by SSD1-V (Kaeberlein and Guarente, 2002).
HomologsS.c. MBP1, SWI6, SWI3
S.p. Spcc5e4.02c, Spbc9b6.11c
D.m. CG6324
R.n. PLA2G6, PSMD10
M.m. PLA2G6, PSMD10
H.s. FLJ10852
R.n. PLA2G6, PSMD10
Primary ReferenceKaeberlein, M., and Guarente, L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 Function in Parallel Pathways to Promote Cell Wall Integrity. Genetics 160, 83-95. [Abstract]
Other ReferencesNasmyth, K., and Dirick, L. (1991). The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast. Cell 66, 995-1013. [Abstract]
Igual, J. C., Johnson, A. L., and Johnston, L. H. (1996). Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity. Embo J 15, 5001-13. [Abstract]
Relevant LinksYPD:
KeywordsSaccharomyces cerevisiae, yeast, replicative, senescence, cell wall, transcription factor, signalling,