OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDominant
StrainPSY316, W303R
DescriptionAddition of the SSD1-V allele to an ssd1-d strain suppresses the short life-span of an MPT5 deletion mutant (Kaeberlein and Guarente, 2002) and extends wild type life-span (Kaeberlein and Guarente, unpublished).
Gene FunctionUnknown. Possible RNA binding protein (Luukkonen and Seraphin, 1999).
Other PhenotypesSSD1-V slightly extends the life-spans of swi4 and ccr4 mutant strains and suppresses the temperature sensitive growth phenotype of mpt5, ccr4, swi4, and swi6 single mutants (Kaeberlein and Guarente, 2002). SSD1-V also suppresses the synthetic lethality caused by deletion of MPT5 in combination with a mutation in SWI4, SWI6, or CCR4 (Kaeberlein and Guarente, 2002). SSD1-V has been shown to suppress mutations that affect cell wall stability (Costigan et al, 1992; Lee et al., 1993), RNA polymerase III activity (Stettler et al., 1993), RNA splicing (Luukkonen and Sepharin, 1999), and PKA activity (Sutton et al., 1991, Uesono et al., 1994).
HomologsS.c. DIS3, MSU1
S.p. Sts5, Spbc609.01
C.e. F48E8.6, C04G2.6, C55A6.6
D.m. CG6413, CG16940
Primary ReferenceKaeberlein, M., and Guarente, L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 Function in Parallel Pathways to Promote Cell Wall Integrity. Genetics 160, 83-95. [Abstract]
Other ReferencesCostigan, C., Gehrung, S., and Snyder, M. (1992). A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth. Mol Cell Biol 12, 1162-78. [Abstract]
Luukkonen, B. G., and Seraphin, B. (1999). A conditional U5 snRNA mutation affecting pre-mRNA splicing and nuclear pre-mRNA retention identifies SSD1/SRK1 as a general splicing mutant suppressor. Nucleic Acids Res 27, 3455-65. [Abstract]
Stettler, S., Chiannilkulchai, N., Hermann-Le Denmat, S., Lalo, D., Lacroute, F., Sentenac, A., and Thuriaux, P. (1993). A general suppressor of RNA polymerase I, II and III mutations in Saccharomyces cerevisiae. Mol Gen Genet 239, 169-76. [Abstract]
Lee, K. S., Irie, K., Gotoh, Y., Watanabe, Y., Araki, H., Nishida, E., Matsumoto, K., and Levin, D. E. (1993). A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. Mol Cell Biol 13, 3067-75. [Abstract]
Uesono, Y., Fujita, A., Toh-e, A., and Kikuchi, Y. (1994). The MCS1/SSD1/SRK1/SSL1 gene is involved in stable maintenance of the chromosome in yeast. Gene 143, 135-8. [Abstract]
Sutton, A., Immanuel, D., and Arndt, K. T. (1991). The SIT4 protein phosphatase functions in late G1 for progression into S phase. Mol Cell Biol 11, 2133-48. [Abstract]
Relevant LinksYPD:
Keywordsyeast, Saccharomyces cerevisiae, replicative, senescence, cell wall, temperature, stress