Namedaz-1
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionMutation of daz-1 has no effect on life span (Arantes-Oliviera et al., 2002).
Gene FunctionMeiotic factor required for oogenesis.
Other Phenotypesdaz-1 mutants are sterile and have a gonad that contains small nuclei and no oocytes (Karashima et al., 2000). Sperm production is normal. Oocyte precursors arrest at meiotic prophase and undergo apoptosis.
HomologsS.c. YBR159, YMR226, YLR426
S.p. Spac4g9.15p, Spac521.03
C.e. C04F6.5, C56G2.6, C06B3.5
D.m. CG13284, CG1444, CG6012
R.n. LOC84013, HSD17B3
M.m. HSD17B12, HSD17B3, RSDR1
H.s. LOC51144
Primary ReferenceArantes-Oliviera, N., Apfeld, J., Dillin, A., and Kenyon, C. (2002). Regulation of life-span by germ line stem cells in Caenorhabditis elegans. Science 295.
Other ReferencesKarashima, T., Sugimoto, A., and Yamamoto, M. (2000). Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis. Development 127, 1069-79. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=daz-1;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=173931
KeywordsCaenorhabditis, elegans, worm, sterility