OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function extends life-span 50-100% depending on the allele. Life-span extension is suppressed by daf-16 (Apfeld and Kenyon, 1999).
Gene FunctionCytosolic dynein heavy chain. Required for proper structure of sensory cilia (Wicks et al., 2000).
Other PhenotypesMutants have defective sensory neurons (Perkins et al. 1986; Gonzcy et al. 1999) and are defective in dye filling (Perkins et al. 1986; Starich et al., 1995). Mutants are dauer defective (Vowels and Thomas, 1992).
HomologsS.c. DYN1
S.p. dhc1
C.e. DHC-1, F55F10.2
D.m. Dhc64c, Dhc93AB, CG15148, kl-5, Dhc98D, Dhc36c, ...
H.s. DNAH9, DNCH1, DNAH17L, DKFZP434A236, DNAH3, DNAH1, ...
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesGonczy, P., Pichler, S., Kirkham, M., and Hyman, A. A. (1999). Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo. J Cell Biol 147, 135-50. [Abstract]
Starich, T. A., Herman, R. K., Kari, C. K., Yeh, W. H., Schackwitz, W. S., Schuyler, M. W., Collet, J., Thomas, J. H., and Riddle, D. L. (1995). Mutations affecting the chemosensory neurons of Caenorhabditis elegans. Genetics 139, 171-88. [Abstract]
Vowels, J. J., and Thomas, J. H. (1992). Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130, 105-23. [Abstract]
Wicks, S. R., de Vries, C. J., van Luenen, H. G., and Plasterk, R. H. (2000). CHE-3, a cytosolic dynein heavy chain, is required for sensory cilia structure and function in Caenorhabditis elegans. Dev Biol 221, 295-307. [Abstract]
Perkins, L. A., Hedgecock, E. M., Thomson, J. N., and Culotti, J. G. (1986). Mutant sensory cilia in the nematode Caenorhabditis elegans. Developmental Biology 117, 456-487. [Abstract]
Relevant LinksWormPD:
KeywordsCaenorhabditis, elegans, worm, neurons, dauer