Nameglp-1
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
Descriptionglp-1(qu158) animals are defective in germ line proliferation and have a life-span that is extended relative to wild-type animals (Arantes-Oliveira et al., 2002). This life-span extension requires daf-16. Two alleles of glp-1 that cause overproliferation of germline cells, glp-1(oz112gf) and glp-1(q485), result in a shortened life-span (Arantes-Oliviera et al., 2002).
Gene FunctionReceptor for a germline-proliferation signal that is produced by the distal tip cells of the somatic gonad (Tax et al., 1994; Henderson et al., 1994; Kimble and White, 1987).
Other PhenotypesIn glp-1 mutants, Z2 and Z3 generate only a few germ cells, which enter meiosis and differentiate as sperm (Austin and Kimble, 1987).
HomologsS.c. AKR1
S.p. Spac6c3.08, Spapb1e7.05
C.e. LIN-12, CRB-1, W02C12.1
D.m. N, CG9138, CRB, DL
R.n. NOTCH2, NOTCH3, JAG1
M.m. NOTCH1, NOTCH2, NOTCH3
H.s. NOTCH1, NOTCH4
Primary ReferenceArantes-Oliviera, N., Apfeld, J., Dillin, A., and Kenyon, C. (2002). Regulation of life-span by germ line stem cells in Caenorhabditis elegans. Science 295. [Abstract]
Other ReferencesTax, F. E., Yeargers, J. J., and Thomas, J. H. (1994). Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Nature 368, 150-4. [Abstract]
Henderson, S. T., Gao, D., Lambie, E. J., and Kimble, J. (1994). lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans. Development 120, 2913-24. [Abstract]
Kimble, J. E., and White, J. G. (1981). On the control of germ cell development in Caenorhabditis elegans. Dev Biol 81, 208-19. [Abstract]
Austin, J., and Kimble, J. (1987). glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans. Cell 51, 589-99. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=glp-1;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=176286
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, sterility