OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
Descriptionmes-1(bn7) animals that lack germ cells have a life-span that is extended by approximately 60% compared to mes-1(bn7) animals that are fertile (Arantes-Oliveira et al., 2002). This life-span extension requires daf-16.
Gene FunctionProtein required for early asymmetric divisions of the germline (Berkowitz and Strome, 2000).
Other PhenotypesHomozygous mes-1 mutant progeny from homozygous mutant mothers are sterile (Capowski et al., 1991).
HomologsS.c. APG1, STE20
S.p. Spcc63.08c, Spac2c4.14
C.e. F54F7.5, B0198.3, W08F4.5
D.m. LD28657, HOP
M.m. PTK6, FLT1, TYK2
H.s. STK24, FLT1, PAK6
Primary ReferenceArantes-Oliviera, N., Apfeld, J., Dillin, A., and Kenyon, C. (2002). Regulation of life-span by germ line stem cells in Caenorhabditis elegans. Science 295. [Abstract]
Other ReferencesCapowski, E. E., Martin, P., Garvin, C., and Strome, S. (1991). Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans. Genetics 129, 1061-72. [Abstract]
Berkowitz, L. A., and Strome, S. (2000). MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells. Development 127, [Abstract]
Relevant LinksWormBase:;class=Locus
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, sterility