NamePCMT
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
Strainunknown
DescriptionOverexpression of PCMT extends life-span by approximately 35% at 29C but has no effect on life-span at 25C (Chavous et al., 2001).
Gene FunctionProtein carboxyl methyltransferase important for repair of abnormal protein aspartyl residues.
Other PhenotypesN/A
HomologsC.e. C10F3.5
M.m. Pcmt1
PCMT1
Primary ReferenceChavous, D. A., Jackson, F. R., and O'Connor, C. M. (2001). Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase. Proc Natl Acad Sci U S A 98, 14814-8. [Abstract]
Other References
Relevant LinksFlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0015276&content=hg-table
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=40668
KeywordsDrosophila melanogaster, fly, damage, stress, protein repair