OrganismMus musculus
Aging PhenotypeShortened life-span
Allele TypeUnknown
Strainmixed inbred C57BL/6129/Sv
DescriptionMice that are heterozygous (m/+) for an allele of p53 that removes the 5` portion of the protein demonstrate decreased cancer, premature aging phenotypes, and shortened life span (Tyner et al., 2002). It has been proposed that this allele of p53 results in increased activity/overexpression.
Gene Functionp53 is a tumor suppressor/DNA-binding transcription factor important for apoptosis.
Other PhenotypesDecreased activity of p53 results in increased cancer and decreased apoptosis. p53 can be deacetylated by mouse SIR2alpha (Vaziri et al., 2001; Luo et al., 2001). Deacetylation of p53 by SIR2 decreases p53 apoptosis promoting activity.
HomologsR.n. TP53, TRP63
M.m. TRP73, TRP63
H.s. TP53, TP63, TP73
Primary ReferenceTyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., Hee Park, S., Thompson, T., Karsenty, G., Bradley, A., and Donehower, L. A. [Abstract]
Other ReferencesLuo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., and Gu, W. (2001). Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107, 137-48. [Abstract]
Vaziri, H., Dessain, S. K., Ng Eaton, E., Imai, S. I., Frye, R. A., Pandita, T. K., Guarente, L., and Weinberg, R. A. (2001). hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-59. [Abstract]
Relevant LinksIARC p53:
Keywordsmouse, mus musculus, p53, tumor suppressor, cancer, apoptosis