InterventionDietary restriction of coenzyme Q
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainBristol N2
DescriptionAdult worms fed a strain of E. coli lacking coenzyme Q (ubiquinone) lived 59% longer than worms fed a standard E.coli strain (Larsen and Clarke, 2002). Dietary restricton of Q also extended the life-span of daf-2, daf-12, daf-16, and clk-1 mutants.
Gene FunctionCoenzyme Q is a redox-active lipid essential for electron transport in aerobic respiration.
Other PhenotypesDietary restriction of coenzyme Q may extend life-span by reducing the production of ROS (Larsen and Clarke, 2002). CLK-1 is an enzyme required for Q production and some clk-1 mutants require dietary Q for viability (Jonassen et al., 2001).
Homologs
Primary ReferenceLarsen, P. L., and Clarke, C. F. (2002). Extension of life-Span in Caenorhabditis elegans by a diet lacking coenzyme Q. Science 295, 120-3. [Abstract]
Other ReferencesJonassen, T., Larsen, P. L., and Clarke, C. F. (2001). A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants. Proc Natl Acad Sci U S A 98, 421-6. [Abstract]
Relevant Links
Keywordsmetabolism, signaling, mitochondria, Caenorhabditis, elegans, worm, oxidative stress, ROS