OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function mutants extend life-span up to 50% (Apfeld and Kenyon, 1999).
Gene FunctionWD40 repeat protein (Fujiwara et al. 1999).
Other PhenotypesMutants are chemotactic defective, slightly small and defective for osmotic avoidance. Ciliated neurons have abnormal stunted ultrastructure. Mutants are dauer defective (Perkins et al., 1988; Vowels and Thomas, 1992).
HomologsS.c. PFS2, PWP2, PRP4, YCR072C, TAF90, SIF2
S.p. Spbc713.04C, Spac227.12, Spbc1289.11, taf72, Spbc354.03, taf73, Spcc1235.09, ...
C.e. C14B1.4, K04G11.4, ZC302.2, R06A4.9, gbp-2, opu-2, ...
D.m. CG9333, wds, CG17437, ebi, CG10931, BG, ...
R.n. Arpc1b, Rn.2568, Gnb2, Gnb1, Strn
M.m. Hira, Sid329, WSB-2, Trip1, Strap, Gnb2-rs1, ...
H.s. WDR5, TBL1, FLJ11287, HPRP8BP, HIRA, SOP2L, ...
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesPerkins, L. A., Hedgecock, E. M., Thomson, J. N., and Culotti, J. G. (1986). Mutant sensory cilia in the nematode Caenorhabditis elegans. Developmental Biology 117, 456-487. [Abstract]
Vowels, J. J., and Thomas, J. H. (1992). Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130, 105-23. [Abstract]
Relevant LinksWormBase:;class=Locus
KeywordsCaenorhabditis, elegans, worm, neurons, dauer