NameMsrA
OrganismMus musculus
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainC57BL/6J
DescriptionMsrA -/- homozygous mutant mice have a 40% shorter life-span than wild type or heterozygote animals (Moskovitz et al., 2001).
Gene FunctionMethionine sulfoxide reductase
Other PhenotypesMsrA -/- mice are sensitive to oxidative stress, accumulate higher levels of protein carbonyls, and demonstrate an atypical walking pattern (Moskovitz et al., 2001).
HomologsR.n. MsrA
D.m. MSRA
Primary ReferenceMoskovitz, J., Bar-Noy, S., Williams, W. M., Requena, J., Berlett, B. S., and Stadtman, E. R. (2001). Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proc Natl Acad Sci U S A 98, 12920-5. [Abstract]
Other References
Relevant LinksJAX: http://www.informatics.jax.org/searches/marker.cgi?27867
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=110265
KeywordsM. musculus, mouse, oxidative stress