OrganismMus musculus
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionMsrA -/- homozygous mutant mice have a 40% shorter life-span than wild type or heterozygote animals (Moskovitz et al., 2001).
Gene FunctionMethionine sulfoxide reductase
Other PhenotypesMsrA -/- mice are sensitive to oxidative stress, accumulate higher levels of protein carbonyls, and demonstrate an atypical walking pattern (Moskovitz et al., 2001).
HomologsR.n. MsrA
Primary ReferenceMoskovitz, J., Bar-Noy, S., Williams, W. M., Requena, J., Berlett, B. S., and Stadtman, E. R. (2001). Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proc Natl Acad Sci U S A 98, 12920-5. [Abstract]
Other References
Relevant LinksJAX:
KeywordsM. musculus, mouse, oxidative stress