OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionMutation of isp-1 results in a 60% increase in mean life-span and 100% increase in maximum life-span. An isp-1 daf-2 double mutant has a life-span that is longer than either single mutant, but the life-span extension of the double mutant is not additive relative to each single mutant.
Gene FunctionIron-sulfur protein of mitochodrial complex III.
Other PhenotypesMutation of isp-1 results in reduced oxygen consumption and increased resistance to oxidative stress,
HomologsS.c. RIP1
S.p. RIP1
D.m. CG7361
R.n. RN.2603
Primary ReferenceFeng, J., Bussiere, F., and Hekimi, S. (2001). Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans. Dev Cell 1, 633-44. [Abstract]
Other References
Relevant LinksLocusLink:
Keywordsoxidative stress, C. elegans, worms, mitochondria, ROS, metabolism, Caenorhabditis, elegans