OrganismMus musculus
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainMixed genetic background
DescriptionTelomerase null (mTR -/-) mice showed age-dependent telomere shortening and shortened lifespan with succeeding generations (Rudolph et al, 1999). Median life span was reduced by 25% in G6 mTR -/- mice compared to wildtype or G1-G3 mTR-/- (18 months compared to 24 months). These mice showed hair graying, hair loss, and ulcerative skin lesions. In addition, they had impaired response to wound healing and hematopoietic ablation, and an increased incidence of cancer (Rudolph et al, 1999).
Gene FunctionRNA component of telomerase
Other PhenotypesCells from mTR -/- mice (G4 and upward) showed chromosomes lacking detectable telomere repeats, aneuploidy, and end-to-end fusions (Blasco et al, 1997).
HomologsH.s. TERC
Primary ReferenceRudolph, K. L., Chang, S., Lee, H. W., Blasco, M., Gottlieb, G. J., Greider, C., and DePinho, R. A. (1999). Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96, 701-12. [Abstract]
Other ReferencesBlasco, M. A., Lee, H. W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., and Greider, C. W. (1997). Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34. [Abstract]
Relevant LinksMGR:
KeywordsMouse, Mus musculus, telomeres, cancer, telomeres, replicative senescence