NameLongevity-associated locus on chromosome 4 [unknown genes(s)]
OrganismHomo sapiens
Aging PhenotypeCorrelation
Allele TypeUnknown
DescriptionA genome wide scan for loci associated with exceptional longevity in humans was performed. 308 exceptionally long-lived individuals (representing 137 sibships) were used for this study. A locus on chromosome 4 was identified that appears to be associated with long life-span in this group of subjects (Puca et al., 2001).
The longevity-associated locus on chromosome 4 was recently identified as MTP (microsomal transfer protein).
Gene FunctionUnknown.
Other PhenotypesSiblings of centenarians are four times more likely to live into their 90s than control siblings (Perls et al., 1998).
Primary ReferencePuca, A. A., Daly, M. J., Brewster, S. J., Matise, T. C., Barrett, J., Shea-Drinkwater, M., Kang, S., Joyce, E., Nicoli, J., Benson, E., Kunkel, L. M., and Perls, T. (2001). A genome-wide scan for linkage to human exceptional longevity identifies a locus [Abstract]
Other ReferencesPerls, T. T., Bubrick, E., Wager, C. G., Vijg, J., and Kruglyak, L. (1998). Siblings of centenarians live longer. Lancet 351, 1560. [Abstract]
Relevant Links
KeywordsH. sapiens, human