|Name||Longevity-associated locus on chromosome 4 [unknown genes(s)]|
|Description||A genome wide scan for loci associated with exceptional longevity in humans was performed. 308 exceptionally long-lived individuals (representing 137 sibships) were used for this study. A locus on chromosome 4 was identified that appears to be associated with long life-span in this group of subjects (Puca et al., 2001).|
The longevity-associated locus on chromosome 4 was recently identified as MTP (microsomal transfer protein).
|Other Phenotypes||Siblings of centenarians are four times more likely to live into their 90s than control siblings (Perls et al., 1998).|
|Primary Reference||Puca, A. A., Daly, M. J., Brewster, S. J., Matise, T. C., Barrett, J., Shea-Drinkwater, M., Kang, S., Joyce, E., Nicoli, J., Benson, E., Kunkel, L. M., and Perls, T. (2001). A genome-wide scan for linkage to human exceptional longevity identifies a locus [Abstract]|
|Other References||Perls, T. T., Bubrick, E., Wager, C. G., Vijg, J., and Kruglyak, L. (1998). Siblings of centenarians live longer. Lancet 351, 1560. [Abstract]|
|Keywords||H. sapiens, human|