InterventionHeat Shock
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainBristol N2
DescriptionTransient sublethal heat shock increases life-span of C. elegans. Heat shock of 4-day old gravid adults at 30 degrees C, ranging in duration from 3-24 hours, produces a 14% increase in subsequent maximum life-span at 20 degrees C. Though small, this extension is reproducible and highly statistically significant (P < 0.001) (Lithgow et al, 1995). In another study, heat shock for 6 hours at 30 degrees C resulted in a significant increase in life-span at 25 degrees C (mean increased by 13%, maximum increased by 18%), but heat shock for 2 or 4 hours did not significantly increase life-span (Yokoyama et al, 2002).
Gene FunctionN/A
Other PhenotypesThe same heat shock regimen that increases life-span also confers increased thermotolerance: animals shifted to a lethal temperature (35 degrees C) after the heat shock survive significantly longer than unshocked controls (Lithgow et al, 1995).
HomologsN/A
Primary ReferenceLithgow, G. J., White, T. M., Melov, S., and Johnson, T. E. (1995). Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A 92, 7540-4. [Abstract]
Other ReferencesYokoyama, K., Fukumoto, K., Murakami, T., Harada, S., Hosono, R., Wadhwa, R., Mitsui, Y., and Ohkuma, S. (2002). Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. FEBS Lett 516 [Abstract]
Relevant Links
KeywordsC. elegans, heat shock, thermotolerance, stress, temperature