InterventionHeat Shock
Alternate Name
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainYPK9
DescriptionTransient sublethal heat shock increases replicative lifespan of yeast cells. Cells were shocked for 2 hrs at 37C prior to the first division, then shocked in the same way a second time immediately after they produced their fourth daughter. This resulted in an average 12% extension in subsequent mean lifespan at 30 degrees C (Shama et al, 1998a). Maximum lifespan did not increase. Age-specific mortality rate is reduced after theat shock relative to controls that were not heat shocked. This difference in age-specific mortality persists for several generations but eventually disappears (Shama et al, 1998a).
Gene FunctionN/A
Other Phenotypes37 degree heat shocks lasting less than 2 hrs or applied at later generations had no effect on lifespan, while higher temperatures reduced lifespan by increasing mortality (Shama et al, 1998a). 1 hr heat-shocks applied daily also shorten lifespan (Shama et al, 1998b). RAS1 and RAS 2 are required for life span extension by this treatment: heat shock of cells mutant for either gene results in a 15-20% shortening of mean lifespan (Shama et al, 1998b). HSP104 is also required; the life span of heat shocked hsp104 cells is unaffected (Shama et al, 1998b).
HomologsN/A
Primary ReferenceShama, S., Lai, C. Y., Antoniazzi, J. M., Jiang, J. C., and Jazwinski, S. M. (1998a). Heat stress-induced life span extension in yeast. Exp Cell Res 245, 379-88. [Abstract]
Other ReferencesShama, S., Kirchman, P. A., Jiang, J. C., and Jazwinski, S. M. (1998b). Role of RAS2 in recovery from chronic stress: effect on yeast life span. Exp Cell Res 245, 368-78. [Abstract]
Relevant Links
KeywordsSaccharomyces, cerevisiae, yeast, heat shock, stress, temperature