InterventionHeat Shock
Alternate Name
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionTransient sublethal heat shock increases replicative lifespan of yeast cells. Cells were shocked for 2 hrs at 37C prior to the first division, then shocked in the same way a second time immediately after they produced their fourth daughter. This resulted in an average 12% extension in subsequent mean lifespan at 30 degrees C (Shama et al, 1998a). Maximum lifespan did not increase. Age-specific mortality rate is reduced after theat shock relative to controls that were not heat shocked. This difference in age-specific mortality persists for several generations but eventually disappears (Shama et al, 1998a).
Gene FunctionN/A
Other Phenotypes37 degree heat shocks lasting less than 2 hrs or applied at later generations had no effect on lifespan, while higher temperatures reduced lifespan by increasing mortality (Shama et al, 1998a). 1 hr heat-shocks applied daily also shorten lifespan (Shama et al, 1998b). RAS1 and RAS 2 are required for life span extension by this treatment: heat shock of cells mutant for either gene results in a 15-20% shortening of mean lifespan (Shama et al, 1998b). HSP104 is also required; the life span of heat shocked hsp104 cells is unaffected (Shama et al, 1998b).
Primary ReferenceShama, S., Lai, C. Y., Antoniazzi, J. M., Jiang, J. C., and Jazwinski, S. M. (1998a). Heat stress-induced life span extension in yeast. Exp Cell Res 245, 379-88. [Abstract]
Other ReferencesShama, S., Kirchman, P. A., Jiang, J. C., and Jazwinski, S. M. (1998b). Role of RAS2 in recovery from chronic stress: effect on yeast life span. Exp Cell Res 245, 368-78. [Abstract]
Relevant Links
KeywordsSaccharomyces, cerevisiae, yeast, heat shock, stress, temperature