OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function mutation increases life-span up to 40% (Apfeld and Kenyon, 1999).
Gene FunctionNot cloned.
Other PhenotypesMutants are dye filling defective and have severely shortened axonemes and ectopic assembly of ciliary structures and microtubules in many sensory neurons; mutants are defective in osmotic avoidance and dauer defective.(Perkins et al., 1988)
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesPerkins, L. A., Hedgecock, E. M., Thomson, J. N., and Culotti, J. G. (1986). Mutant sensory cilia in the nematode Caenorhabditis elegans. Developmental Biology 117, 456-487. [Abstract]
Relevant LinksWormBase:;class=Locus
KeywordsCaenorhabditis, elegans, worm, neurons, dauer