Nameche-13
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function mutation increases life-span up to 40% (Apfeld and Kenyon, 1999).
Gene FunctionNot cloned.
Other PhenotypesMutants are dye filling defective and have severely shortened axonemes and ectopic assembly of ciliary structures and microtubules in many sensory neurons; mutants are defective in osmotic avoidance and dauer defective.(Perkins et al., 1988)
HomologsN/A
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesPerkins, L. A., Hedgecock, E. M., Thomson, J. N., and Culotti, J. G. (1986). Mutant sensory cilia in the nematode Caenorhabditis elegans. Developmental Biology 117, 456-487. [Abstract]
Relevant LinksWormBase:
http://www.wormbase.org/db/gene/locus?name=che-13;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=186607
KeywordsCaenorhabditis, elegans, worm, neurons, dauer