|
| | Name | ZDS2 |
|---|
| Organism | Saccharomyces cerevisiae (replicative) |
|---|
| Aging Phenotype | Shortened life-span |
|---|
| Allele Type | Deletion |
|---|
| Strain | W303 |
|---|
| Description | Deletion results in short life span about 80% of wild-type (Roy and Runge, 2000) |
|---|
| Gene Function | Unknown. |
|---|
| Other Phenotypes | Null mutation decreases rDNA silencing five-fold, increases silencing at a mutant HMR that lacks the Rap1p-binding site in the HMR-E silencer
threefold, and has no effect on telomeric silencing. Deletion decreases rDNA silencing, increases rDNA recombination, and increases level of phosphorylated Sir3p (Roy and Runge, 2000) |
|---|
| Homologs | S.c. ZDS1, STU1
S.p. Spac637.14
C.e. T23F11.3
|
|---|
| Primary Reference | Roy, N., and Runge, K. W. (2000). Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Curr Biol 10, 111-4. [Abstract]
|
|---|
| Other References | none
|
|---|
| Relevant Links |
Deprecated: Function ereg_replace() is deprecated in /home/www/html/research/bioage/genesdb/gene.php on line 69
SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=zds2
Deprecated: Function ereg_replace() is deprecated in /home/www/html/research/bioage/genesdb/gene.php on line 69
YPD: http://www.proteome.com/databases/YPD/reports/ZDS2.html
|
|---|
| Keywords | telomeres, chromatin, silencing, rDNA, nucleolus, recombination, yeast, replicative senescence, Saccharomyces, cerevisiae |
|---|
|