OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionDeletion results in short life span about 80% of wild-type (Roy and Runge, 2000)
Gene FunctionUnknown.
Other PhenotypesNull mutation decreases rDNA silencing five-fold, increases silencing at a mutant HMR that lacks the Rap1p-binding site in the HMR-E silencer
threefold, and has no effect on telomeric silencing. Deletion decreases rDNA silencing, increases rDNA recombination, and increases level of phosphorylated Sir3p (Roy and Runge, 2000)
HomologsS.c. ZDS1, STU1
S.p. Spac637.14
C.e. T23F11.3
Primary ReferenceRoy, N., and Runge, K. W. (2000). Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Curr Biol 10, 111-4. [Abstract]
Other Referencesnone
Relevant LinksSGD:
Keywordstelomeres, chromatin, silencing, rDNA, nucleolus, recombination, yeast, replicative senescence, Saccharomyces, cerevisiae