OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
DescriptionDeletion increases life span by 37%, requires Sir3p for life span extension (Roy and Runge, 2000)
Gene Functionunknown
Other PhenotypesNull mutation causes a 100-fold decrease in telomeric silencing, a nine-fold increase in rDNA silencing, reduces rDNA recombination, and decreases Sir3p phosphorylation (Roy and Runge, 2000)
HomologsS.c. ZDS2
S.p. Spac637.14
Primary ReferenceRoy, N., and Runge, K. W. (2000). Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Curr Biol 10, 111-4. [Abstract]
Other Referencesnone
Relevant LinksSGD:
Keywordstelomeres, chromatin, silencing, rDNA, nucleolus, recombination, yeast, replicative senescence, Saccharomyces, cerevisiae