NameUTH3
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBKy1-14c
DescriptionMutation extends life span by approximately 30% (Kennedy et al., 1995).
Gene FunctionUnknown, gene has never been cloned.
Other PhenotypesMutant has increased resistance to cold stress and starvation (Kennedy et al., 1995).
HomologsN/A
Primary ReferenceKennedy, B. K., Austriaco, N. R., Zhang, J., and Guarente, L. (1995). Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80, 485-96. [Abstract]
Other ReferencesNone
Relevant LinksNone
Keywordsyeast, replicative senescence, Saccharomyces, cerevisiae, starvation resistance