OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionMutation extends life span by approximately 30% (Kennedy et al., 1995).
Gene FunctionUnknown, gene has never been cloned.
Other PhenotypesMutant has increased resistance to cold stress and starvation (Kennedy et al., 1995).
Primary ReferenceKennedy, B. K., Austriaco, N. R., Zhang, J., and Guarente, L. (1995). Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80, 485-96. [Abstract]
Other ReferencesNone
Relevant LinksNone
Keywordsyeast, replicative senescence, Saccharomyces, cerevisiae, starvation resistance