NameUTH1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBKy1-14c
DescriptionMutation increases life span by approximately 15% (Kennedy et al., 1995).
Gene FunctionUnknown.
Other PhenotypesMutant has increased resistance to cold stress and starvation (Kennedy et al., 1995).
Null mutant is resistant to hydrogen peroxide, but sensitive to paraquat and oxygen (Bandara et al., 1998).
Null mutant is more resistant to heat shock than wild type (Mouassite et al., 2000)
HomologsS. c. SIM1, SUN4, NCA3, YMR244W
S.p. psu1, Spbc2g2.17c, Spcc74.07c, Spac25B8.19c
Primary ReferenceKennedy, B. K., Austriaco, N. R., Zhang, J., and Guarente, L. (1995). Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80, 485-96. [Abstract]
Other ReferencesBandara, P. D., Flattery-O'Brien, J. A., Grant, C. M., and Dawes, I. W. (1998). Involvement of the Saccharomyces cerevisiae UTH1 gene in the oxidative- stress response. Curr Genet 34, 259-68. [Abstract]
Mouassite, M., Camougrand, N., Schwob, E., Demaison, G., Laclau, M., and Guerin, M. (2000). The 'SUN' family: yeast SUN4/SCW3 is involved in cell septation. Yeast 16, 905-19. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=UTH1
YPD: http://www.proteome.com/databases/YPD/reports/UTH1.html
Keywordsyeast, replicative senescence, Saccharomyces, cerevisiae, oxidative stress, starvation resistance, heat shock