OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeOverexpression
DescriptionTransgenic mice called alpha MUPA overexpress urokinase-type plasminogen activator in many brain sites including the hypothalamus (Miskin and Masos, 1997). These mice consume less food (by 20%) , have reduced body weight (by 20%) and length (by 6%), and have increased life span (by 20%).
Gene FunctionUrokinase-type plasminogen activator is a protease which functions in fibrinolysis and extracellular proteolysis (Miskin and Masos, 1997).
Other PhenotypesAlpha MUPA mice have reduced levels of blood sugar and smaller litter size and birth frequency compared to their parental wild type control (Miskin and Masos, 1997). Their body temperature is reduced (Miskin et al, 1999).
Primary ReferenceMiskin, R., and Masos, T. (1997). Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity, J Gerontol A Biol Sci Med Sci 52, B118-24. [Abstract]
Other ReferencesMiskin, R., Masos, T., Yahav, S., Shinder, D., and Globerson, A. (1999). AlphaMUPA mice: a transgenic model for increased life span, Neurobiol Aging 20, 555-64. [Abstract]
Relevant LinksLocusLink:
KeywordsMus musculus, mouse, caloric restriction, neurons