Nameunc-78
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionMutation has no effect on life span (Lakowski and Hekimi, 1998).
Gene FunctionWD repeat family member. Important for muscle structure.
Other PhenotypesMutants move slowly (Waterston et al., 1980).
HomologsS.c. AIP1, YLR222C, YCR072C, ASC1, TAF90, CDH1 ...
S.p. Spac9G1.05, Spac227.12, Spcc18.05c, Spac25H1.08c, Spbc1A4.07c, Spbc31F10.13c ...
C.e. K08F9.2, C14B1.4, K04G11.4, ZC302.2, W07E6.2, R06A4.9 ...
D.m. CG10724, wds, CG17437, CG10191, CG6322, Nle ...
R.n. Rn.2568, Gnb2, Rn.5890, Rn.5827, Rn.9262, Coro1b ...
M.m. Wdr1, Apaf1, Stat3ip1, Fyr, Gnb2, Pafah1ba ...
H.s. WDR1, WDR5, APAF1, FLJ10458, H12.3, HPRP4p ...
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesWaterston, R. H., Thomson, J. N., and Brenner, S. (1980). Mutants with altered muscle structure of Caenorhabditis elegans. Dev Biol 77, 271-302. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=unc-78;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=180631
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons