OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
Descriptionunc-76(e911) allele extends male life span approximately 50%. No effect on hermaphrodite life span (Gems and Riddle, 2000)
Gene FunctionFEZ family protein. Involved in axon-axon interactions.
Other PhenotypesMutants are uncoordinated (Desai et al., 1988).
HomologsD.m. CG3981
R.n. RN5468
H.s. FEZ2, FEZ1
Primary ReferenceGems, D., and Riddle, D. L. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154, 1597-610. [Abstract]
Other ReferencesDesai, C., Garriga, G., McIntire, S. L., and Horvitz, H. R. (1988). A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature 336, 638-46. [Abstract]
Relevant LinksWormBase:;class=Locus
KeywordsCaenorhabditis, elegans, worm, neurons, sex-specific